P097 The efficacy of benzoxazole derivatives (B-98) as 5-lipooxygenase inhibitor and the change of T cell profiles in acute murine colitis model
نویسندگان
چکیده
منابع مشابه
[Benzoxazole derivative B-98 ameliorates dextran sulfate sodium-induced acute murine colitis and the change of T cell profiles in acute murine colitis model].
BACKGROUND/AIMS The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to evaluate the effects of B-98, a newly synthesized benzoxazole derivatives and a novel 5-LO inhibitor, in a mouse model of IBD induced by dextran sulfate sodium (DSS). METHODS C57BL/6 mice were randoml...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2013
ISSN: 1873-9946
DOI: 10.1016/s1873-9946(13)60119-1